Not your Target Gener? Search again
|NCBI Gene ID:||1029|
|Official Full Name:||cyclin dependent kinase inhibitor 2A|
|Summary:|| This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012].|
There is no existing raPOOL for your gene, hence a custom raPOOL set up service is required. Please add this to cart and proceed to choose the raPOOL scale required where 2, 5 or 10 nmol is sufficient for 20, 50 or 100 reactions with the recommended use of 100 pmol raPOOL per reaction.
Custom raPOOL Set Up Service
One-time raPOOL set up fee for a new gene.
Price: € 529,00
Includes design of new probes against target RNA. Charged on top of raPOOL 2, 5 or 10 price.
Charged once only, subsequent order of raPOOL follows raPOOL-2, 5 or 10 pricing.
Price: € 1.155,00
Amount provided: 10 nmol. Sufficient for 100 reactions.
Price: € 325,00
Amount provided: 2 nmol. Sufficient for 20 rxns.
5 nmol raPOOL
Price: € 675,00
Amount provided: 5 nmol. Sufficient for 50 reactions.