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|NCBI Gene ID:||2064|
|Official Full Name:||erb-b2 receptor tyrosine kinase 2|
|Summary:|| This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].|
There is no existing raPOOL for your gene, hence a custom raPOOL set up service is required. Please add this to cart and proceed to choose the raPOOL scale required where 2, 5 or 10 nmol is sufficient for 20, 50 or 100 reactions with the recommended use of 100 pmol raPOOL per reaction.
Custom raPOOL Set Up Service
One-time raPOOL set up fee for a new gene.
Price: € 529,00
Includes design of new probes against target RNA. Charged on top of raPOOL 2, 5 or 10 price.
Charged once only, subsequent order of raPOOL follows raPOOL-2, 5 or 10 pricing.
Price: € 1.155,00
Amount provided: 10 nmol. Sufficient for 100 reactions.
Price: € 325,00
Amount provided: 2 nmol. Sufficient for 20 rxns.
5 nmol raPOOL
Price: € 675,00
Amount provided: 5 nmol. Sufficient for 50 reactions.