Quick Order of raPOOL for ERBB3

Not your Target Gener? Search again

Please verify & confirm your selected Target Gene:

Official Symbol:	ERBB3
NCBI Gene ID:	2065
Aliases:	ErbB-3 FERLK HER3 LCCS2 MDA-BF-1 VSCN1 c-erbB-3 c-erbB3 erbB3-S p180-ErbB3 p45-sErbB3 p85-sErbB3
Official Full Name:	erb-b2 receptor tyrosine kinase 3
Species:	human
Summary:	This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008].

 

Buy raPOOLs for ERBB3

There is no existing raPOOL for your gene, hence a custom raPOOL set up service is required. Please add this to cart and proceed to choose the raPOOL scale required where 2, 5 or 10 nmol is sufficient for 20, 50 or 100 reactions with the recommended use of 100 pmol raPOOL per reaction.