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Quick Order of raPOOL for HTT

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Please verify & confirm your selected Target Gene:

Official Symbol:
HTT
NCBI Gene ID:3064
Aliases: HD
IT15
LOMARS
Official Full Name:huntingtin
Species:human
Summary: Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression. [provided by RefSeq, Jul 2016].

 

Buy raPOOLs for HTT

There is no existing raPOOL for your gene, hence a custom raPOOL set up service is required. Please add this to cart and proceed to choose the raPOOL scale required where 2, 5 or 10 nmol is sufficient for 20, 50 or 100 reactions with the recommended use of 100 pmol raPOOL per reaction.


Custom raPOOL Set Up Service   Click here for more information about Custom raPOOL Set Up Service
One-time raPOOL set up fee for a new gene.
Price: € 529,00

Includes design of new probes against target RNA. Charged on top of raPOOL 2, 5 or 10 price.

Charged once only, subsequent order of raPOOL follows raPOOL-2, 5 or 10 pricing.
 

raPOOL 10   Click here for more information about raPOOL 10
10nmol raPOOL
Price: € 1.155,00

Amount provided: 10 nmol. Sufficient for 100 reactions.

HPLC-purified, freeze-dried.
 

raPOOL 2   Click here for more information about raPOOL 2
2nmol raPOOL
Price: € 325,00

Amount provided: 2 nmol. Sufficient for 20 rxns.

HPLC-purified, freeze-dried.
 

raPOOL 5   Click here for more information about raPOOL 5
5 nmol raPOOL

Price: € 675,00

Amount provided: 5 nmol. Sufficient for 50 reactions.

HPLC-purified, freeze-dried.