Quick Order of siPOOL for PTEN

Not your Target Gene? Search again

Please verify & confirm your selected Target Gene:

Official Symbol:	PTEN
NCBI Gene ID:	5728
Content / Scale:	10q23del BZS CWS1 DEC GLM2 MHAM MMAC1 PTEN1 PTENbeta TEP1
Official Full Name:	phosphatase and tensin homolog
Species:	human
Summary:	This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015].

 

Buy a siPOOL (siRNA Pool) for PTEN

Order a complex pool of 30 siRNAs (siPOOL) for the specific gene knockdown of human gene PTEN.

Product Description:

siPOOLs (siRNA pools) are high complexity pools of 30 optimally selected siRNAs designed to specifically knock-down the target gene of your choice.

Why 30 siRNAs?

Using 30 siRNAs at a picomolar concentration dilutes and significantly minimizes the off-target effects of each siRNA, therefore highly increasing the on-target specificity. On the other hand, individual siRNAs or low complexity siRNA pools containing only 2-4 siRNAs often display dominant off-target profiles and exhibit variable target gene knock-downs.

Product Formats:

• Individual siPOOLs: a pool of 30 distinct siRNAs provided as a single reagent
• siPOOL kits: include an individual siPOOL and a standard negative control

As reaction numbers depend on transfection efficiencies and well/plate format used, please refer to our FAQ section or siPOOL transfection protocol for more information.

Click "Login to add to Cart" to add multiple items to your shopping cart by logging into your siTOOLs Biotech account or by creating a new one.

For faster shopping, click "Order now as a Guest" to send us your Order now, then create an Account later.