<
siTOOLs Biotech Webshop Quick Order

Webshop

Order siTOOLs Biotech's products


Quick Order of siPOOL for BRCA1

Not your Target Gene? Search again

Please verify & confirm your selected Target Gene:

Official Symbol:
BRCA1
NCBI Gene ID:672
Content / Scale: BRCAI
BRCC1
BROVCA1
FANCS
IRIS
PNCA4
PPP1R53
PSCP
RNF53
Official Full Name:BRCA1 DNA repair associated
Species:human
Summary: This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2020].

 

Buy a siPOOL (siRNA Pool) for BRCA1

Order a complex pool of 30 siRNAs (siPOOL) for the specific gene knockdown of human gene BRCA1.

Product Description:

siPOOLs (siRNA pools) are high complexity pools of 30 optimally selected siRNAs designed to specifically knock-down the target gene of your choice.

Why 30 siRNAs?

Using 30 siRNAs at a picomolar concentration dilutes and significantly minimizes the off-target effects of each siRNA, therefore highly increasing the on-target specificity. On the other hand, individual siRNAs or low complexity siRNA pools containing only 2-4 siRNAs often display dominant off-target profiles and exhibit variable target gene knock-downs.

Product Formats:

  • Individual siPOOLs: a pool of 30 distinct siRNAs provided as a single reagent
  • siPOOL kits: include an individual siPOOL and a standard negative control

As reaction numbers depend on transfection efficiencies and well/plate format used, please refer to our FAQ section or siPOOL transfection protocol for more information.

Click "Login to add to Cart" to add multiple items to your shopping cart by logging into your siTOOLs Biotech account or by creating a new one.

For faster shopping, click "Order now as a Guest" to send us your Order now, then create an Account later.


siPOOL- 2   Click here for more information about siPOOL- 2
2 nmol siPOOL
Price: € 295,00

2 nmol siPOOL
Pool of pre-selected ~30 siRNAs against the target gene.

HPLC-purified, in 50µM solution.
 

siPOOL- 5   Click here for more information about siPOOL- 5
5 nmol siPOOL
Price: € 548,00

5 nmol siPOOL, pool of 30 pre-selected siRNAs against the target gene.

HPLC-purified, in 50µM solution.
 

siPOOL- 5 Kit   Click here for more information about siPOOL- 5 Kit
5 nmol siPOOL
5 nmol negative control siPOOL
Price: € 699,00

This kit contains the target-specific siPOOL and a negative control siPOOL against sequences not found in mouse, rat or human.

Amount provided: 5 nmol / siPOOL.

HPLC-purified, in 50µM solution.
 

siPOOL-10   Click here for more information about siPOOL-10
10 nmol siPOOL
Price: € 692,00

10 nmol siPOOL, pool of 30 pre-selected siRNAs against the target gene.

HPLC-purified, in 50µM solution.
 

siPOOL-10 Kit   Click here for more information about siPOOL-10 Kit
10 nmol siPOOL
10 nmol negative control siPOOL
Price: € 925,00

This kit contains the target-specific siPOOL and a negative control siPOOL against sequences not found in mouse, rat or human.

Amount provided: 10 nmol / siPOOL.

HPLC-purified, in 50µM solution.
 

siPOOL-20   Click here for more information about siPOOL-20
20 nmol siPOOL
Price: € 1.041,00

20 nmol siPOOL, pool of 30 pre-selected siRNAs against the target gene.

HPLC-purified, in 50µM solution.
 

siPOOL-20 kit   Click here for more information about siPOOL-20 kit
20 nmol siPOOL
20 nmol negative control siPOOL
Price: € 1.369,00

This kit contains the target-specific siPOOL and a negative control siPOOL against sequences not found in mouse, rat or human.

Amount provided: 20 nmol / siPOOL.

HPLC-purified, in 50µM solution.
 

siPOOL-40   Click here for more information about siPOOL-40
40 nmol siPOOL
Price: € 1.665,00

40 nmol siPOOL, pool of 30 pre-selected siRNAs against the target gene.

HPLC-purified, in 50µM solution.
 

siPOOL-40 kit   Click here for more information about siPOOL-40 kit
40 nmol siPOOL
40 nmol negative control siPOOL
Price: € 2.565,00

This kit contains the target-specific siPOOL and a negative control siPOOL against sequences not found in mouse, rat or human.

Amount provided: 40 nmol / siPOOL.

HPLC-purified, in 50µM solution.