Quick Order of siPOOL for MTA1

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Official Symbol:	MTA1
NCBI Gene ID:	9112
Content / Scale:
Official Full Name:	metastasis associated 1
Species:	human
Summary:	This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].

 

Buy a siPOOL (siRNA Pool) for MTA1

Order a complex pool of 30 siRNAs (siPOOL) for the specific gene knockdown of human gene MTA1.

Product Description:

siPOOLs (siRNA pools) are high complexity pools of 30 optimally selected siRNAs designed to specifically knock-down the target gene of your choice.

Why 30 siRNAs?

Using 30 siRNAs at a picomolar concentration dilutes and significantly minimizes the off-target effects of each siRNA, therefore highly increasing the on-target specificity. On the other hand, individual siRNAs or low complexity siRNA pools containing only 2-4 siRNAs often display dominant off-target profiles and exhibit variable target gene knock-downs.

Product Formats:

• Individual siPOOLs: a pool of 30 distinct siRNAs provided as a single reagent
• siPOOL kits: include an individual siPOOL and a standard negative control

As reaction numbers depend on transfection efficiencies and well/plate format used, please refer to our FAQ section or siPOOL transfection protocol for more information.

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