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Official Symbol:	CD59
NCBI Gene ID:	966
Aliases:	16.3A5 1F5 EJ16 EJ30 EL32 G344 HRF-20 HRF20 MAC-IP MACIF MEM43 MIC11 MIN1 MIN2 MIN3 MIRL MSK21 p18-20
Official Full Name:	CD59 molecule (CD59 blood group)
Species:	human
Summary:	This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008].

 

Buy raPOOLs for CD59

There is no existing raPOOL for your gene, hence a custom raPOOL set up service is required. Please add this to cart and proceed to choose the raPOOL scale required where 2, 5 or 10 nmol is sufficient for 20, 50 or 100 reactions with the recommended use of 100 pmol raPOOL per reaction.