siTOOLs Biotech's Research

Awards & Grants

Grants

In-house Research and Development

Eigenbetriebliche Forschung und Entwicklung

Die siTOOLs Biotech GmbH hat für das folgende eigenbetriebliche Forschungs- und Entwicklungsvorhaben einen positiven Bescheid der Bescheinigungsstelle Forschungszulage (BSFZ) erhalten:
„Neues enzymatisches Hochdurchsatz-Verfahren zur Herstellung von komplexen siRNA Pools aus DNA-Oligo Pools“
Ziel des Vorhabens ist die Entwicklung eines neuen enzymatischen Hochdurchsatzverfahrens zur effizienten Herstellung komplexer siRNA-Pools aus DNA-Oligopools.

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In-house Research and Development

siTOOLs Biotech GmbH has received a positive assessment from the German Certification Body for Research Allowance (BSFZ) for the following in-house research and development project:
“New Enzymatic High-Throughput Method for the Production of Complex siRNA Pools from DNA Oligo Pools”
The project aims to develop a new enzymatic high-throughput method for the efficient production of complex siRNA pools from DNA oligo pools.

Cluster for Nucleic Acid Therapeutics Munich (C-NATM)

Granting: Federal Ministry of Education and Research of Germany (BMBF)

Program Partners: Technical University of Munich (TUM) and Ludwig-Maximilians-Universität München (LMU)

Award Date: July 2022

Program info: Cluster for Nucleic Acid Therapeutics Munich (C-NATM) is an innovation network for the development of RNA-based drugs. It is made up of research institutions such as siTOOLs Biotech, pharmaceutical companies, and private enterprise in the Munich region. It will receive five million euros in funding annually from the German government, the Free State of Bavaria, and in part from participating companies. More info.

Next generation advanced RNA inhibition therapy to treat cardiometabolic disease - LiverTarget

Granting: HORIZON-AG - HORIZON Action Grant Budget-Based (EU Commission)

Award Date: May 2022

Program info: LiverTarget aims at exploiting siTOOLs Biotech’s and other partners’ years of research in the field of cardiometabolic research, the identification of ceramide pathways and inflammatory targets, and the development of novel siRNA technologies and lipid formulations, to:

  1. Generate innovative siRNA pools and synthetic mRNAs to regulate ceramide and inflammatory targets in the liver.
  2. Formulate them in established human-approved liver-targeting lipid nanoparticles (LNP).
  3. Determine their efficacy in vivo in preclinical mouse models of obesity, diabetes, non-alcoholic fatty liver disease (NAFLD) and atherosclerosis.
  4. Complete the necessary safety and toxicology evaluation of the most promising lead candidates and prepare the preclinical evaluation dossier for the European Medicines Agency (EMA). More info.

Development of an application method for a systemic varroa treatment with lithium chloride in honey bee colonies - subproject B (EAsyLife)

Organization: Federal Ministry of Food and Agriculture of Germany (BMEL)

Grant Date: Feb 2021

Program info: Honey bees are indispensable pollinator for the ecosystem as well as for agricultural production. For both, honeybees and beekeeper the worldwide distributed parasitic mite Varroa destructor represents the greatest threat. Varroosis has been proven to be the main driver for periodic colony losses and economic damage. Currently, there is no satisfactory treatment available that meets all requirements of the beekeeper. With the discovery of lithium chloride (LiCl) we present a new active substance with a high varroacidal potential combining a high efficacy against varroa mites with good tolerability for bees. Due to the systemic mode of action LiCl can be easily applied. The main objective of the project is to develop a practicable application for this new compound in order to reduce colony losses and economic losses of the beekeeper. More info.

Awards

2nd prize in Bavaria Business Plan Contest

Awards: 2nd prize in Bavaria Business Plan Contest, 3rd Prize at the Hochschul Gründerpreis 2014 (held in parallel)

Granting: BayStartUp

Award Date: July 2014

Program info: Organized by the innovation and entrepreneurship initiative "Netzwerk Nordbayern" in cooperation with Siemens AG, the 2nd prize for the Nordbayern (North Bavaria) Business Plan contest held on 23 July 2014 was awarded to siTOOLs Biotech. The prize consisted of 7500 EUR in winnings. siTOOLs also won the 3rd prize in a preceding competition for the Hochschule Gründerpreis (University Founder Award).