Innovative preclinical research tools for the reliable study of gene function


Our products, siPOOLsTM (pooled siRNA for gene silencing by RNA interference) & raPOOLsTM (pooled biotinylated oligos for RNA affinity purification) combine high complexity pooling, detailed design and quality production, to achieve unrivalled specificity in gene targeting. By avoiding off targets, experiments become efficient and reproducible, yielding results that you can trust.

With extensive experience in RNAi screening, siTOOLs Biotech also supports its customers with a high level of scientific knowledge, cutting-edge bioinformatics, and outstanding technical service.



Latest News


11
JUN
siTOOLs Biotech partners with Galen Lab Supplies to distribute products/services in the USA

siTOOLs Biotech launches The Phenovault - free database and analysis suite for RNAi/CRISPR screens. Go to Phenovault website.




UPCOMING EVENTS


International Meeting for the German Society of Cell Biology



Sep 17       Lepizig, Germany




LATEST FROM BLOG


17

Apr

Low complexity pooling does not prevent siRNA off-targets

Summary: Low-complexity siRNA pooling (e.g. Dharmacon siGENOME SMARTpools) does not prevent siRNA off-targets.  It may in fact exacerbate off-target effects.  Only high-complexity pooling (siPOOL...




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OUR Technology

Learn About siPOOL Technology



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Customer Reviews


"Having tested 75,000 siRNA sequences, it is quite apparent that off-target effects dominate siRNA-mediated phenotypes. In contrast, in our hands, siPOOLs have much greater predictive power…." - Dr. Derek Welsbie, Assistant Professor, University of California San Diego

"…siPOOLs are highly target-specific and show an efficient knockdown of the target already in the range of low nanomolar concentrations..." - Dr. Mona Malz, Senior Scientist, German Cancer Research Center (DKFZ)

"…client service offered by siTOOLs is excellent. We get advice and even hands-on support immediately whenever necessary." - Dr. Peter Dietrichs, Post-doctoral Scientist, Friedrich-Alexander-University of Erlangen-Nürnberg

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QUICK LINKS


raPOOLs


Studying long non-coding RNAs? Use raPOOLs to discover interacting partners

Publications


Publications using siPOOLs or raPOOLs including siPOOL technology paper: Hannus et al., NARS, 2014

siPOOL Cancer Toolbox


Manipulate multiple cancer pathways reliably and affordably

siPOOL Libraries


Learn about the siPOOL 505 human kinase library

Technotes


Download siPOOL information and other detailed technical notes

FAQs





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