Innovative preclinical research tools for the reliable study of gene function

Our products, siPOOLsTM (pooled siRNA for gene silencing by RNA interference) & raPOOLsTM (pooled biotinylated oligos for RNA affinity purification) combine high complexity pooling, detailed design and quality production, to achieve unrivalled specificity in gene targeting. By avoiding off targets, experiments become efficient and reproducible, yielding results that you can trust.

With extensive experience in RNAi screening, siTOOLs Biotech also supports its customers with a high level of scientific knowledge, cutting-edge bioinformatics, and outstanding technical service.

Latest News

Announcement: Webshop ordering now available for individual purchase of 2 nmol siPOOLs from the siPOOL human kinase library and siPOOL cancer toolbox.


Axonlab/siTOOLs Seminar - RNAi and CRISPR in Functional Genomics

Nov 15       Biozentrum der Universitaet Basel, Klingelbergstrasse 70, Room Number 104, 9 am - 12 pm




Low hit validation rate for Dharmacon siGENOME screens

Good experimental design is important when validating hits from RNAi screens.  Off-target effects from single siRNAs and low-complexity siRNA pools (e.g. Dharmacon siGENOME) result in high false-...

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OUR Technology

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Customer Reviews

"Having tested 75,000 siRNA sequences, it is quite apparent that off-target effects dominate siRNA-mediated phenotypes. In contrast, in our hands, siPOOLs have much greater predictive power…." - Dr. Derek Welsbie, Assistant Professor, University of California San Diego

"…siPOOLs are highly target-specific and show an efficient knockdown of the target already in the range of low nanomolar concentrations..." - Dr. Mona Malz, Senior Scientist, German Cancer Research Center (DKFZ)

"…client service offered by siTOOLs is excellent. We get advice and even hands-on support immediately whenever necessary." - Dr. Peter Dietrichs, Post-doctoral Scientist, Friedrich-Alexander-University of Erlangen-Nürnberg

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