We drive RNA research
Complex siRNAs pools, rRNA depletion kits, and RNA Library Preparation kits for any species
Gene silencing with siPOOLs
Complex siRNA pools for any target gene and species
rRNA Depletion with riboPOOLs
Optimized ribosomal RNA removal for RNA-Seq and ribosome profiling
RNA Library Preparation Kit
Validated on intact & degraded RNA as well as FFPE samples.
Publications using our products
Publications citing siPOOLs
Prion protein conversion at two distinct cellular sites precedes fibrillisation Ribes et al. (2023) Nature Communications.
The function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways Berkane et al. (2023) Nature Communications
Genome-wide RNAi screen identifies novel players in human 60S subunit biogenesis including key enzymes of polyamine metabolism Dörner et al. (2022) Nucleic Acids Research
Publications citing riboPOOLs
Selective gene expression maintains human tRNA anticodon pools during differentiation Gao et al. (2024) Nature Cell Biology
Comparative Analysis of rRNA Removal Methods for RNA-Seq Differential Expression in Halophilic Archaea Pastor et al. (2022) Biomolecules
Comparison of rRNA depletion methods for efficient bacterial mRNA sequencing Wahl et al. (2022) Scientific Reports
Latest News
High Input rRNA Depletion Kit
On March 1st, we will be launching the High-Input riboPOOL Kit - the only rRNA depletion kit that handles up to 30 µg of total RNA in a single reaction.
If you would like to know more about it, feel free to reach out: info@sitools.de
NEW Product!
We just launched our new RNA Library Preparation Kit "ARGO". Check it out on the product page.
What our customers say
Dr. Athena Sklias (Post-doctoral researcher, Center for Integrative Genomics, University of Lausanne, Switzerland). Publication: Sklias et al. (2024), Nucleic Acids Research; used the Drosophila melanogaster riboPOOL.
".... We exchanged a lot with siTOOLs members to optimise the composition of the riboPOOL due to certain particularities of rRNA sequences in D. melanogaster. The members of the company were very responsive from the first minute and very keen to adapt the pools to provide a maximal ribodepletion. We reached a ribodepletion rate of 90 to 97% of rRNAs in our finally reads, we couldn’t hope for something better!"
Dr. Peter-Christian Klöhn (Principal Investigator, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK)
"The innovative solution of siPOOLs with 30 single siRNAs per pool is our first choice for conducting gene candidate approaches where gene loss-of-function has to be studied for dozens of genes. This approach is highly cost-effective and labor-saving when compared to gene silencing with single siRNAs or small pools of randomly selected siRNAs."