We drive RNA research!
RNA research tools and kits, including siRNA pools, rRNA depletion kits, and RNA library preparation kits for any species
rRNA Depletion with riboPOOLs
Optimized ribosomal RNA removal for RNA-Seq and ribosome profiling
All Products
Our products are built to advance your RNA research.
Gene silencing with siPOOLs
Complex siRNA pools for any target gene and species
Publications using siTOOLs products
Publications citing siPOOLs for Gene Silencing
Peer-reviewed studies showcasing siRNA pools for efficient gene knockdown and RNA interference applications
- Prion protein conversion at two distinct cellular sites precedes fibrillisation — Ribes et al. (2023), Nature Communications
- The function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways — Berkane et al. (2023), Nature Communications
- Genome-wide RNAi screen identifies novel players in human 60S subunit biogenesis — Dörner et al. (2022), Nucleic Acids Research
Publications citing riboPOOLs
Peer-reviewed studies showcasing rRNA depletion kits for RNA-Seq and transcriptome analysis
- Selective gene expression maintains human tRNA anticodon pools during differentiation — Gao et al. (2024), Nature Cell Biology
- Comparative Analysis of rRNA Removal Methods for RNA-Seq Differential Expression in Halophilic Archaea — Pastor et al. (2022), Biomolecules
- Comparison of rRNA depletion methods for efficient bacterial mRNA sequencing — Wahl et al. (2022), Scientific Reports
Explore all riboPOOL publications
Latest News
Breaking the 5 µg Barrier for RNA-Seq Workflows
Discover our new high-input rRNA depletion kit for RNA-Seq: High-Input riboPOOLs. With efficient ribosomal RNA depletion from 5–30 µg total RNA, it improves data quality and transcript detection. As a result, you can achieve more efficient RNA sequencing. Learn more in our latest blog post on rRNA depletion for RNA research tools and kits.
NEW Product!
We just launched the High-Input riboPOOL rRNA depletion kit for high-input RNA-Seq workflows. It efficiently removes ribosomal RNA (rRNA) from up to 30 µg total RNA. As a result, it improves whole transcriptome sequencing, gene expression analysis, and long-read sequencing.
NEW Product!
Introducing our new RNA library preparation kit (ARGO) for RNA sequencing workflows. It complements our RNA research tools and kits and supports RNA-Seq library prep, transcriptome analysis, and gene expression studies. As a result, you can streamline your RNA workflows across many applications.
What our customers say
Dr. Athena Sklias (Post-doctoral researcher, Center for Integrative Genomics, University of Lausanne, Switzerland). Publication: Sklias et al. (2024), Nucleic Acids Research; used the Drosophila melanogaster riboPOOL.
"...We worked closely with the siTOOLs team to optimize the riboPOOL composition or the specific rRNA sequences in D. melanogaster. From the start, the team was highly responsive and eager to adapt the pools for maximum rRNA depletion. As a result, we achieved 90-97% rRNA depletion in our final reads, which exceeded our expectations."
More about riboPOOLs
Dr. Peter-Christian Klöhn (Principal Investigator, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK)
"The innovative siPOOL approach, combining 30 individual siRNAs per pool, is our first choice for gene knockdown and gene silencing studies across multiple targets. It is especially useful for loss-of-function screens involving dozens of genes. In addition, this method is cost-effective and time-saving compared to using single siRNAs or small, randomly selected siRNA pools."