Publications using our products
Publications citing siPOOLs
Prion protein conversion at two distinct cellular sites precedes fibrillisation Ribes et al. (2023) Nature Communications.
The function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways Berkane et al. (2023) Nature Communications
Genome-wide RNAi screen identifies novel players in human 60S subunit biogenesis including key enzymes of polyamine metabolism Dörner et al. (2022) Nucleic Acids Research
Publications citing riboPOOLs
Selective gene expression maintains human tRNA anticodon pools during differentiation Gao et al. (2024) Nature Cell Biology
Comparative Analysis of rRNA Removal Methods for RNA-Seq Differential Expression in Halophilic Archaea Pastor et al. (2022) Biomolecules
Comparison of rRNA depletion methods for efficient bacterial mRNA sequencing Wahl et al. (2022) Scientific Reports
Latest News
Newest Ribo-Seq rRNA Depletion Kit
The Mouse tRNA Ribo-Seq riboPOOL is designed to efficiently deplete transfer RNA (tRNA) from mouse RNA samples during ribosome profiling sample preparation.
Grüße vom Oktoberfest
Prost to progress! 🍻 The siTOOLs team discussing RNA research over beers at the Oktoberfest.
Please note that our office will be closed on October 3rd for a public holiday. Enjoy the festivities. 🙂
Minimize your RNA contaminants
The RiboCut Marker is a high-resolution molecular marker, which facilitates precise excision of 30-mer RPFs from preparative gels. It can be applied to RPFs derived from any species (e.g. human, mouse, rat, C.elegans, D. melanogaster).
What our customers say
"Drosophila melanogaster is an excellent tool to study the function of snoRNA in vivo as the genes coding for these non coding RNAs are not highly duplicated as in humans. As mature snoRNAs cannot be captured with a polyA pulldown, we had to opt for a ribodepletion solution in order to perform a whole transcriptome sequencing by TGIRT-seq. The ribodepletion kit from siTOOLs seemed as an evident solution. We exchanged a lot with siTOOLs members to optimise the composition of the riboPOOL due to certain particularities of rRNA sequences in D. melanogaster. The members of the company were very responsive from the first minute and very keen to adapt the pools to provide a maximal ribodepletion. We reached a ribodepletion rate of 90 to 97% of rRNAs in our finally reads, we couldn’t hope for something better!"
Dr. Athena Sklias (Post-doctoral researcher, Center for Integrative Genomics, University of Lausanne, Switzerland). Publication: Sklias et al. (2024), Nucleic Acids Research; used the Drosophila melanogaster riboPOOL.
More about riboPOOLs
"The innovative solution of siPOOLs with 30 single siRNAs per pool is our first choice for conducting gene candidate approaches where gene loss-of-function has to be studied for dozens of genes. This approach is highly cost-effective and labor-saving when compared to gene silencing with single siRNAs or small pools of randomly selected siRNAs."
Dr. Peter-Christian Klöhn (Principal Investigator, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK)