|Learn about siRNA off-target effects. A reference-rich guide describing the mechanism by which siRNA off-targets are produced, the penetrance and extent of siRNA off-target effects, and the impact siRNA off-targets have on experimental research.
Download Technote 1: siRNA Off-target Effects - Causes, Extent & Impact
|Understand current established techniques to reduce siRNA off-target effects, including the siPOOL approach. From siRNA concentration, chemical modification and siRNA design, this is a detailed technical overview of each approach and their pros and cons. We also provide a non-bias assessment of the effectiveness of each approach using data-driven bioinformatic analysis.
Download Technote 2: Ways to Reduce siRNA Off-target Effects
|A snapshot overview of our products and services.
Download the siTOOLs Overview
|A detailed guide with an introduction to the RNAi off-target problem and how siPOOLs were developed to counter them. Covers the three main features of siPOOLs - high complexity pooling, detailed bioinformatics-based design and quality production process - and the benefits they confer. Includes proof-of-concept data, customer testimonials and case study applications.
Download the siPOOL Guide
|siPOOLs are ideal for reliable high-throughput functional genomic screening. Learn more about the siPOOL human kinase library, the screening benefits it confers and associated data in this brochure.
Download siPOOL Human Kinase Library brochure
|The siPOOL cancer toolbox is a useful exploratory tool for scientists seeking an easy method to disrupt key cancer genes singly or in combination.
Download siPOOL Cancer Toolbox brochure
|The Phenovault is a free-access data analysis and reagent/gene evaluation tool that leverages new insights based on historical RNAi/CRISPR screening data. To schedule a presentation about Phenovault, please contact us.
Download The Phenovault brochure
Download The Phenovault poster
|To further validate that the loss-of-function phenotype produced by a siPOOL is specific to the targeted gene, we offer a siPOOL-resistant rescue sequence. When expressed in a plasmid construct, target gene function is restored which rescues/reverses the loss-of-function phenotype.
Download siPOOL-resistant rescue information.