Our landmark paper demonstrating siPOOL proof-of-concept data
Hannus M. et. al.:
siPools: highly complex but accurately defined siRNA pools eliminate off-target effects. Nucleic Acids Res 42(12): 8049-61
Ziegler, C. et. al
Publications using siPOOLs/raPOOLs
(2019) The long nonâcoding RNA LINC00941 and SPRR5 are novel regulators of human epidermal homeostasis. EMBO Rep
Choi, K. et. al
(2019) Binary Targeting of siRNA to Hematologic Cancer Cells In Vivo Using LayerâbyâLayer Nanoparticles. Adv Funct Mater
Spies, J. et. al
(2019) 53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage. Nat Cell Biol
Dietrich, P. et al.
(2019) Neuroblastoma RAS Viral Oncogene Homolog (NRAS) Is a Novel Prognostic Marker and Contributes to Sorafenib Resistance in Hepatocellular Carcinoma. Neoplasia
Vendramin, R. et al.
(2018) SAMMSON fosters cancer cell fitness by concertedly enhancing mitochondrial and cytosolic translation. Nat Struct Mol Biol
Coscia, F. et al.
(2018) Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer. Cell
Kästle, M. et al.
FKBP51 modulates steroid sensitivity and NFκB signalling: A novel anti-inflammatory drug target. Eur J Immunol
Stieglitz, D. et al.
BMP6-induced modulation of the tumor micro-milieu. Oncogene
Weber, A., Schwarz, S. C. et al.
Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1. Nat Commun
9, 2929 (2018)
Noethel, B. et al.
Transition of responsive mechanosensitive elements from focal adhesions to adherens junctions upon epithelial differentiation. Mol Biol Cell
Prestigiacomo, V., and Suter-Dick, L.
Nrf2 protects stellate cells from Smad-dependent cell activation. PLoS One
13, e0201044 (2018)
Vallin, B. et al.
Novel short isoforms of adenylyl cyclase as negative regulators of cAMP production. Biochim Biophys Acta - Mol Cell Res
1865: 1326–1340 (2018)
Rietscher, K. et al.
14-3-3 Proteins Regulate Desmosomal Adhesion via Plakophilins.” Journal of cell science
Jiang, P. et al.
Genome-Scale Signatures of Gene Interaction from Compound Screens Predict Clinical Efficacy of Targeted Cancer Therapies.” Cell Systems
6(3): 343–354.e5. (2018).
So, D. et al.
Cervical Cancer Is Addicted to SIRT1 Disarming the AIM2 Antiviral Defense. Oncogene
Klingenberg, M. et al.
The lncRNA CASC9 and RNA Binding Protein HNRNPL Form a Complex and Co-Regulate Genes Linked to AKT Signaling. Hepatology
Polycarpou-Schwarz, M. et al.
The Cancer-Associated Microprotein CASIMO1 Controls Cell Proliferation and Interacts with Squalene Epoxidase Modulating Lipid Droplet Formation. Oncogene
Zeiner, P. S. et al.
CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival. Acta Neuropathol. Commun.
6, 18 (2018).
Ziegelmann, B et al.
Lithium chloride effectively kills the honey bee parasite Varroa destructor by a systemic mode of action. Scientific Reports
8(1), 683 (2018)
Dietrich, P. et al.
Wild type Kirsten rat sarcoma is a novel microRNA-622-regulated therapeutic target for hepatocellular carcinoma and contributes to sorafenib resistance. Gut
Dietrich, P. et al.
Wild-type KRAS is a novel therapeutic target for melanoma contributing to primary and acquired resistance to BRAF inhibition. Oncogene
Kaller, M. et al.
Loss of p53-inducible long non-coding RNA LINC01021 increases chemosensitivity. Oncotarget
8, 102783–102800 (2017).
Ilina, E. I. et al.
Effects of soluble CPE on glioma cell migration are associated with mTOR activation and enhanced glucose flux. Oncotarget
8, 67567–67591 (2017).
Goyal, A. et al.
A cautionary tale of sense-antisense gene pairs: independent regulation despite inverse correlation of expression. Nucleic Acids Research
Steinbach, A. et al.
ERAP1 overexpression in HPV-induced malignancies: A possible novel immune evasion mechanism. Oncoimmunology
6, e1336594 (2017).
Sluch, V. M. et al.
Enhanced Stem Cell Differentiation and Immunopurification of Genome Engineered Human Retinal Ganglion Cells. STEM CELLS Translational Medicine.
Armento, A. et al. Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors. International Journal of Oncology 51(2), 702-714 (2017)
Nötzold, L. et al.
The long non-coding RNA LINC00152 is essential for cell cycle progression through mitosis in HeLa cells. Scientific Reports
7, 2265 (2017)
Welsbie, D. S. et al.
Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons. Neuron
94(6), 1142–1154.e6 (2017)
Ruivo, M. T. G. et al.
Host AMPK Is a Modulator of Plasmodium Liver Infection. Cell Rep.
Treiber, T. et al.
A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. Mol. Cell
66, 270–284.e13 (2017).
Seiler, J. et al. The lncRNA VELUCT strongly regulates viability of lung cancer cells despite its extremely low abundance. Nucleic Acids Res. (2017)
Goyal, A. et al.
Challenges of CRISPR/Cas9 applications for long non-coding RNA genes Nucleic Acids Res.
Ott, C. A. et al.
Induction of exportin-5 expression during melanoma development supports the cellular behavior of human malignant melanoma cells. Oncotarget
7, 62292–62304 (2016).
Adriaens, C. et al.
p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity. Nat. Med.
Coll-Bonfill, N. et al.
Slug is increased in vascular remodeling and induces a smooth muscle cell proliferative phenotype. PLoS One
11, 1–21 (2016).
Kordaß, T. et al.
SOX5 is involved in balanced MITF regulation in human melanoma cells. BMC Med. Genomics
9, 10 (2016).
Hauptmann, J. et al.
Biochemical isolation of Argonaute protein complexes by Ago-APP. Proc. Natl. Acad. Sci.
112, 11841–11845 (2015).
Blirando, K. et al.
The stellate vascular smooth muscle cell phenotype is induced by IL-1β via the secretion of PGE2 and subsequent cAMP-dependent protein kinase A activation. Biochim. Biophys. Acta.
1853, 3235–3247 (2015).
Tuncay, H. et al.
JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis. Nat. Commun.
6, 8128 (2015).
Schraivogel, D. et al.
Importin-β facilitates nuclear import of human GW proteins and balances cytoplasmic gene silencing protein levels. Nucleic Acids Res.
Schönemann L. et al.
: Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33. Genes Dev.
28(21), 2381-93 (2014)
Prasad, V. et al.
Chemical induction of unfolded protein response enhances cancer cell killing through lytic virus infection. J. Virol.
88, 13086–13098 (2014).
Patrick C.H. Lo, PhD
: siRNAs: Jumping in the Pool to Avoid Hitting Innocent Bystanders. BioTechniques
Advances in RNAi Tools and Technologies. Genetic Engineering & Biotechnology News
. April 33(8): 20-22, 24 (2013)