Complex siRNA pooling is especially important for silencing lncRNAs
One advantage of pooling siRNAs is that the pool tends to silence about as well as any single siRNA.
siPOOLs: robust reagents for gene silencing
Although we talk a lot about off-targets, one of the main advantages of siPOOLs (complex siRNA pools) compared to single siRNAs or mini-pools (Dharmacon) is that they provide near optimum silencing of target genes.
Cutting the Gordian Knot of RNAi off-targets
The C911 siRNA control generated a lot of excitement in the RNAi world when it emerged ~11 years ago.
