Human riboPOOL

The Human riboPOOL is designed to efficiently deplete ribosomal RNA (rRNA) from human RNA samples. The product is compatible with most downstream applications, including different next generation sequencing workflows (both short and long-read sequencing).

The Human riboPOOL is optimized for high-quality and intact (RIN > 7) RNA samples. For depletion of rRNA in FFPE/degraded sample, see Human FFPE/Degraded RNA riboPOOL. 

Working on ribosome profiling? Check our Human Ribo-Seq riboPOOL


The Human riboPOOL covers the following sequences:

Sequence Type Covered
28S rRNA Cytosolic Yes
18S  rRNA Cytosolic Yes
5.8S  rRNA Cytosolic Yes
5S rRNA Cytosolic Yes
12S  rRNA Mitochondrial Yes
16S  rRNA Mitochondrial Yes


Remarkably, only about 1-2% of the human genome encodes for proteins. The remaining portion, once considered "junk DNA," contains regulatory elements and non-coding regions critical for gene regulation and function.



  • Enzyme-free, fast & easy workflow
  • Compatible with most downstream applications
  • Wide range of input RNA amounts
  • Possibility of combining with other riboPOOLs
  • Compatible with lab automated workflows


Figure 1 Bioanalyzer profiles of Human total RNA before and after depletion with Human riboPOOL.

Available Formats

riboPOOLs kits with cleanUP module

riboPOOL Probes Only