siPOOLs

siPOOLs (siRNA pools) are high complexity pools of 30 optimally designed siRNAs designed to specifically knock-down the target gene of your choice and improve reliability of results (Hannus et al., 2014). The pooling approach counters the bulk of unpredictable off-target hits induced by individual siRNAs by diluting their concentrations below thresholds that stimulate phenotypes. With proprietary design algorithms, siRNA sequences within siPOOLs are also optimized for maximal transcript coverage, efficient hybridization and filtered against paralogues, enabling highly efficient and specific gene silencing.