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Official Symbol: | PEG10 |
NCBI Gene ID: | 23089 |
Content / Scale: |
EDR HB-1 MEF3L Mar2 Mart2 RGAG3 RTL2 SIRH1 |
Official Full Name: | paternally expressed 10 |
Species: | human |
Summary: | This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. [provided by RefSeq, Oct 2014]. |
Order a complex pool of 30 siRNAs (siPOOL) for the specific gene knockdown of human gene PEG10.
siPOOLs (siRNA pools) are high complexity pools of 30 optimally selected siRNAs designed to specifically knock-down the target gene of your choice.
Using 30 siRNAs at a picomolar concentration dilutes and significantly minimizes the off-target effects of each siRNA, therefore highly increasing the on-target specificity. On the other hand, individual siRNAs or low complexity siRNA pools containing only 2-4 siRNAs often display dominant off-target profiles and exhibit variable target gene knock-downs.
As reaction numbers depend on transfection efficiencies and well/plate format used, please refer to our FAQ section or siPOOL transfection protocol for more information.
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siPOOL- 2
2 nmol siPOOL Price: € 295,00 |
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2 nmol siPOOL Pool of pre-selected ~30 siRNAs against the target gene. HPLC-purified, in 50µM solution. |
siPOOL- 5
5 nmol siPOOL Price: € 548,00 |
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5 nmol siPOOL, pool of 30 pre-selected siRNAs against the target gene. HPLC-purified, in 50µM solution. |
siPOOL- 5 Kit
5 nmol siPOOL 5 nmol negative control siPOOL Price: € 699,00 |
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This kit contains the target-specific siPOOL and a negative control siPOOL against sequences not found in mouse, rat or human. Amount provided: 5 nmol / siPOOL. HPLC-purified, in 50µM solution. |
siPOOL-10
10 nmol siPOOL Price: € 692,00 |
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10 nmol siPOOL, pool of 30 pre-selected siRNAs against the target gene. HPLC-purified, in 50µM solution. |
siPOOL-10 Kit
10 nmol siPOOL 10 nmol negative control siPOOL Price: € 925,00 |
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This kit contains the target-specific siPOOL and a negative control siPOOL against sequences not found in mouse, rat or human. Amount provided: 10 nmol / siPOOL. HPLC-purified, in 50µM solution. |
siPOOL-20
20 nmol siPOOL Price: € 1.041,00 |
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20 nmol siPOOL, pool of 30 pre-selected siRNAs against the target gene. HPLC-purified, in 50µM solution. |
siPOOL-20 kit
20 nmol siPOOL 20 nmol negative control siPOOL Price: € 1.369,00 |
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This kit contains the target-specific siPOOL and a negative control siPOOL against sequences not found in mouse, rat or human. Amount provided: 20 nmol / siPOOL. HPLC-purified, in 50µM solution. |
siPOOL-40
40 nmol siPOOL Price: € 1.665,00 |
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40 nmol siPOOL, pool of 30 pre-selected siRNAs against the target gene. HPLC-purified, in 50µM solution. |
siPOOL-40 kit
40 nmol siPOOL 40 nmol negative control siPOOL Price: € 2.565,00 |
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This kit contains the target-specific siPOOL and a negative control siPOOL against sequences not found in mouse, rat or human. Amount provided: 40 nmol / siPOOL. HPLC-purified, in 50µM solution. |