Quick Order of siPOOL for HBG1

Not your Target Gene? Search again

Please verify & confirm your selected Target Gene:

Official Symbol:	HBG1
NCBI Gene ID:	3047
Content / Scale:	HBG-T2 HBGA HBGR HSGGL1 PRO2979
Official Full Name:	hemoglobin subunit gamma 1
Species:	human
Summary:	The human beta-globin gene cluster located on chromosome 11 spans about 45 kb and includes five functional genes and one pseudogene. The order of genes from 5' to 3' is: epsilon, G-gamma, A-gamma, beta 1 pseudogene, delta, and beta, or HBE1, HBG2, HBG1, HBBP1, HBD and HBB, respectively. These beta-like genes have the same overall exonic structure, leading to the conclusion that they are derived from one ancestral gene. The epsilon- and the two gamma-globin genes are expressed in early embryonic and fetal erythroid tissues, respectively, while the delta- and beta-globin genes are expressed in adult life. Developmental expression of these genes is controlled by a locus control region (LCR) that exists upstream of the HBE1 gene, and it includes five major DNase I hypersensitive sites and several enhancer regions. Two epsilon chains combine with two zeta chains to constitute the embryonic hemoglobin Hb Gower I, while two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Two gamma chains combine with two alpha chains to make fetal hemoglobin HbF. In addition, two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of total hemoglobin. Mutations in either the gene cluster region or LCR can result in beta-thalassemias and beta-hemoglobinopathies. Sickle cell anemia and beta-thalassemia result from mutation and absence, respectively, of the beta-globin chain. [provided by RefSeq, May 2017].

 

Buy a siPOOL (siRNA Pool) for HBG1

Order a complex pool of 30 siRNAs (siPOOL) for the specific gene knockdown of human gene HBG1.

Product Description:

siPOOLs (siRNA pools) are high complexity pools of 30 optimally selected siRNAs designed to specifically knock-down the target gene of your choice.

Why 30 siRNAs?

Using 30 siRNAs at a picomolar concentration dilutes and significantly minimizes the off-target effects of each siRNA, therefore highly increasing the on-target specificity. On the other hand, individual siRNAs or low complexity siRNA pools containing only 2-4 siRNAs often display dominant off-target profiles and exhibit variable target gene knock-downs.

Product Formats:

• Individual siPOOLs: a pool of 30 distinct siRNAs provided as a single reagent
• siPOOL kits: include an individual siPOOL and a standard negative control

As reaction numbers depend on transfection efficiencies and well/plate format used, please refer to our FAQ section or siPOOL transfection protocol for more information.

Click "Login to add to Cart" to add multiple items to your shopping cart by logging into your siTOOLs Biotech account or by creating a new one.

For faster shopping, click "Order now as a Guest" to send us your Order now, then create an Account later.