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Official Symbol: | PTPRF |
NCBI Gene ID: | 5792 |
Content / Scale: |
BNAH2 LAR |
Official Full Name: | protein tyrosine phosphatase receptor type F |
Species: | human |
Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]. |
Order a complex pool of 30 siRNAs (siPOOL) for the specific gene knockdown of human gene PTPRF.
siPOOLs (siRNA pools) are high complexity pools of 30 optimally selected siRNAs designed to specifically knock-down the target gene of your choice.
Using 30 siRNAs at a picomolar concentration dilutes and significantly minimizes the off-target effects of each siRNA, therefore highly increasing the on-target specificity. On the other hand, individual siRNAs or low complexity siRNA pools containing only 2-4 siRNAs often display dominant off-target profiles and exhibit variable target gene knock-downs.
As reaction numbers depend on transfection efficiencies and well/plate format used, please refer to our FAQ section or siPOOL transfection protocol for more information.
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siPOOL- 2
2 nmol siPOOL Price: € 295,00 |
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2 nmol siPOOL Pool of pre-selected ~30 siRNAs against the target gene. HPLC-purified, in 50µM solution. |
siPOOL- 5
5 nmol siPOOL Price: € 548,00 |
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5 nmol siPOOL, pool of 30 pre-selected siRNAs against the target gene. HPLC-purified, in 50µM solution. |
siPOOL- 5 Kit
5 nmol siPOOL 5 nmol negative control siPOOL Price: € 699,00 |
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This kit contains the target-specific siPOOL and a negative control siPOOL against sequences not found in mouse, rat or human. Amount provided: 5 nmol / siPOOL. HPLC-purified, in 50µM solution. |
siPOOL-10
10 nmol siPOOL Price: € 692,00 |
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10 nmol siPOOL, pool of 30 pre-selected siRNAs against the target gene. HPLC-purified, in 50µM solution. |
siPOOL-10 Kit
10 nmol siPOOL 10 nmol negative control siPOOL Price: € 925,00 |
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This kit contains the target-specific siPOOL and a negative control siPOOL against sequences not found in mouse, rat or human. Amount provided: 10 nmol / siPOOL. HPLC-purified, in 50µM solution. |
siPOOL-20
20 nmol siPOOL Price: € 1.041,00 |
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20 nmol siPOOL, pool of 30 pre-selected siRNAs against the target gene. HPLC-purified, in 50µM solution. |
siPOOL-20 kit
20 nmol siPOOL 20 nmol negative control siPOOL Price: € 1.369,00 |
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This kit contains the target-specific siPOOL and a negative control siPOOL against sequences not found in mouse, rat or human. Amount provided: 20 nmol / siPOOL. HPLC-purified, in 50µM solution. |
siPOOL-40
40 nmol siPOOL Price: € 1.665,00 |
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40 nmol siPOOL, pool of 30 pre-selected siRNAs against the target gene. HPLC-purified, in 50µM solution. |
siPOOL-40 kit
40 nmol siPOOL 40 nmol negative control siPOOL Price: € 2.565,00 |
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This kit contains the target-specific siPOOL and a negative control siPOOL against sequences not found in mouse, rat or human. Amount provided: 40 nmol / siPOOL. HPLC-purified, in 50µM solution. |