Quick Order of siPOOL for CCN4

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Official Symbol:	CCN4
NCBI Gene ID:	8840
Content / Scale:	WISP1 WISP1-OT1 WISP1-UT1 WISP1c WISP1i WISP1tc
Official Full Name:	cellular communication network factor 4
Species:	human
Summary:	This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011].

 

Buy a siPOOL (siRNA Pool) for CCN4

Order a complex pool of 30 siRNAs (siPOOL) for the specific gene knockdown of human gene CCN4.

Product Description:

siPOOLs (siRNA pools) are high complexity pools of 30 optimally selected siRNAs designed to specifically knock-down the target gene of your choice.

Why 30 siRNAs?

Using 30 siRNAs at a picomolar concentration dilutes and significantly minimizes the off-target effects of each siRNA, therefore highly increasing the on-target specificity. On the other hand, individual siRNAs or low complexity siRNA pools containing only 2-4 siRNAs often display dominant off-target profiles and exhibit variable target gene knock-downs.

Product Formats:

• Individual siPOOLs: a pool of 30 distinct siRNAs provided as a single reagent
• siPOOL kits: include an individual siPOOL and a standard negative control

As reaction numbers depend on transfection efficiencies and well/plate format used, please refer to our FAQ section or siPOOL transfection protocol for more information.

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